Concussion: Temporary Power Outage

One of the most dramatic conditions in medicine is the concussion – the total and immediate paralysis of brain function that follows a blow to the head. Typically, the victim  loses consciousness and all reflexive muscle activity for seconds to moments. Blood pressure and heart rate may fall and breathing might stop, effects that are usually brief and unnoticed but which on rare occasion cause immediate death. As consciousness returns, the victim seems confused. He does not recall the fall or the blow. Depending on the seriousness of the injury, he suffers a variable period of time during which he remembers nothing new. He asks repetitive questions about what happened and may seem aggressive or out of character. Normality may reassert itself quickly after a concussion, but sometimes several weeks or months of irritability, insomnia, mood change, headaches, and dizziness follow. In other cases, a period of normality, the lucid interval, may be followed by headache, confusion and drowsiness, indicating more severe trauma to the brain and its surrounding tissues.

Concussion of some degree occurs in almost all “closed head injuries,” defined those in which there are no skull fractures or penetrating injuries to the brain. Depending on the trauma involved, symptoms vary from momentary stunning to prolonged coma, but the mechanism of initial paralysis of brain function is always the same. Understanding that mechanism makes it easier to understand delayed worsening and persistent symptoms that sometimes occur afterwards.

How concussions happen

Concussions happen because the brain has the consistency of Jello and is only loosely tethered inside the rigid skull, mainly at the base. When the head accelerates after a blow, or decelerates because of a fall, the brain keeps moving after the skull has stopped. First the cerebral hemispheres slam into the skull in one direction, and then they rebound in the opposite direction. The temporal lobes, where memories form, are particularly vulnerable to impact damage.

Loss of consciousness, however, comes from movement of the tiny brain stem, which emerges from beneath the two large cerebral hemispheres and connects them with the spinal cord. As the heavy cerebral hemispheres above move, the brainstem bends, rotating first in one direction and then in the other. Inside the midbrain, the top part of the brainstem, a group of cells called the reticular activating system reacts with shock and shuts down all communication between brain and body. The power failure lasts anywhere from seconds to weeks, depending on  the degree of rotational force in the midbrain and the amount of stretching and shearing  of nerve cell connections.

Added Problems

Prolonged symptoms, however , usually indicate more widespread damage to the brain in the form of contusions (bruises) and hemorrhages, which cause delayed swelling and worse symptoms. In addition, bleeding from small veins on the surface of the brain (subdural hemorrhage) or between the skull and the dura mater, the tough fibrous lining around the brain (epidural hemorrhage) can occur after seemingly minor concussions. The bleeding stretches, then ruptures more blood vessels, and the growing accumulation of blood puts increasing pressure on the brain.  In 2009, the actress Natasha Richardson died from this kind of complication, soon after a relatively minor fall while skiing. Ronald Reagan suffered  much slower development  of a subdural accumulation of blood following a fall from a horse. Surgical evacuation of the accumulated blood returned him to normal.

After The Concussion

After a head injury, it is very important for the victim to be accompanied by someone who knows him, in order to alert medical personnel to subtle changes in personality or cognitive ability. Most people suffering loss of consciousness will undergo CT or MRI scans, though this is probably unnecessary in mild cases in which the victim has returned to normality quickly. But even after a normal scan, observation, including waking and checking the victim every few hours at night for the first 24 hours, is prudent. If confusion persists after a concussion, the victim should be hospitalized until it clears, and observed carefully after discharge for 24-48 hours.

Most post concussive symptoms like headache, insomnia, irritability and lightheadedness resolve over a few months, requiring only simple medications like ibuprofen and sensible habits such as avoiding alcohol, eating well, sleeping enough, exercising and managing stress.

Repetitive concussions over a lifetime, as suffered in a sport like boxing, clearly damage the brain, producing decline in memory and cognitive abilities, as well as slurred speech and motor symptoms resembling Parkinson’s disease. Recent research suggests that brain injuries may induce progressive change some brain proteins, producing, over a long period, an Alzheimer’s like deterioration in function. The recent attention to the long term effects of other sports related head injuries, especially in professional athletes, stems from this research.

Do Helmets Help

Do helmets protect people from concussions? Helmets do reduce brain damage from trauma in sports like biking and rock climing, but they do it by protecting the skull from fracturing. To dampen the movement of the brain within the skull  – the mechanism of injury in concussion- the diameter of the helmet would have to be so large that it would be impossible to wear.  I have heard many people express surprise about concussions they experienced while wearing helmets in sports like skiing. But if you understand that the skull stops moving in a fall before the brain inside does, you understand that, no, a helmet does not stop a concussion from happening.

 

 

The Problem with Stress: No Fighting or Fleeing

…grant me the serenity
to accept the things I cannot change;
courage to change the things I can;
and wisdom to know the difference….

from The Serenity Prayer, by Reinhold Niebuhr

     Picture an early human moving through the quiet forest, intent on the prey he’s tracking. His pace is steady and his mind focused. Suddenly a bear bursts through the trees.  Emotional centers in primitive parts  the hunter’s brain fire off  threat messages which race through the sympathetic nervous system to his adrenal glands—little thumb size organs buried in fat and sitting on top of the kidneys.  Almost instantly, each gland responds with a burst of adrenalin from its central core, the adrenal medulla. Danger also prompts his pituitary gland to pour out a big dose of adrenocorticotropin (ACTH), a hormone that speeds through the blood to the adrenal cortex, the outer 80% of the gland. In response, the gland releases cortisol, a powerful glucocorticoid hormone involved in energy regulation.

The hunter’s pulse and blood pressure shoot up.  His airways dilate and he breathes faster.  His vision narrows and sharpens. Anticipating action, his muscles and liver free glucose and fat from storage.  By the time he races to a nearby tree to haul himself to safety,  the cascade of neural and hormonal events has shifted his metabolism from quiet homeostasis (maintenance of normal function) to an active state designed for fleeing….or for fighting if the bear climbs too.  When the bear loses interest and wanders away, our early man’s activated physiology reverts to routine functioning. He climbs down, resumes his methodical hunt and cooks his game over an open fire. From sundown to sunup, he sleeps.

Now consider a modern man as he rushes through his urban environment. He becomes anxious and then angry when his train is late. As he hails a cab he narrowly misses being hit by an oncoming car. Horns blare.  He flops down in the back seat of the cab, fumbling for his ringing cell phone, only to hear that his boss is angry because he is late.  Inside our overweight modern man’s body,  early hunter physiology whips his adrenal glands into action – over and over and over. But he does not get to fight or flee. Worse yet, the threats in his environment do not lose interest and wander away.  He will be on edge all day, and perhaps late into the night.  After a few drinks, a few smokes, a fast food meal and some paperwork, he falls asleep in front of the TV, finally stumbling into bed in the wee hours of the morning. By 6AM he’s starting over, sleep-deprived.

The adrenal gland connection

In both early and modern humans, the brain-adrenal connection is heavily influenced by environment, genetic makeup, lifestyle and memory of previous experiences. We learn fear and make habits of emotional responses. While animal research can’t take into account human mental components of stress, it has provided useful physical insights, especially about the adrenal connection to chronic stress. Experiments in “rat micro-societies” refined the fight-or-flight concept and divided it into aggressive defense and passive defeat responses, an important distinction because each type activates different parts of the adrenal glands.

Rats responded with passive defeat when a task like pushing a lever sometimes produced food, sometimes didn’t, sometimes in one place, sometimes in another, and sometimes not at all. The consequences of the rats’ actions were uncontrollable and feedback didn’t help them learn.  In these circumstances the adrenal cortex overproduced cortisol.  If you think the passive defeat experiments resemble average life, then you’ll guess, correctly, that chronic stress in people might also trigger elevated cortisol levels.

Aggressive defense responses to the rat equivalent of being mugged, in contrast, activated primarily the adrenal medulla, which takes charge of the immediate activity necessary to survive a threat by producing an adrenalin rush – a burst of the hormones epinephrine and norepinephrine. In states of fear and/or anger, we experience this rush as rapid pulse, elevated blood pressure, increased breathing rate, flushing, pallor and dry mouth.

In our early hunter these adrenal responses are sequential. First comes the adrenalin rush which helps him survive.  Following just behind,  the adrenal cortex ramps up hormone production to help restore normality–to restock energy supplies, dampen pain and divert resources from routine activities.The system is designed for short bursts of danger, not for chronic immersion in mental stress.

The metabolic syndrome connection

Beginning in 2002, researchers began to correlate adrenal hormone abnormalities with the modern plague of the metabolic syndrome—abdominal obesity, insulin resistance, diabetes and high blood pressure, all reliable side effects of exposure to excessive cortisol, whether it comes from drugs like prednisone or from  pituitary or adrenal gland diseases. (See note on Cushing’s disease below).  No one thinks cortisol and stress are wholly responsible for our metabolic epidemic, but many hope that the stress connection will help lead to a solution.

Counteracting the stress response

Stress researchers uniformly conclude that short of retreating from the world, the only major defense that counteracts the effects of stress is regular physical activity which dissipates some of the energy mobilized for action.  The best results come from superimposing physical activity on a lifestyle that accommodates enduring human needs: sufficient sleep, diet suitable for an ancient physiology, good social network and engagement in focused activity that has personal value. Even then, coping strategies are necessary.

A Note on Cushing’s Disease

    The most dramatic demonstration of the results of too much cortisol occurs in patients with Cushing’s disease, usually caused by a pituitary gland tumor which overstimulates  the adrenal cortex.  In these patients, muscles are thin and weak, and excess weight is concentrated in the trunk and face and neck.  Patients have red, jowly faces and skin scored by purplish stretch marks and poorly healed wounds. Bones are robbed of calcium and osteoporotic upper backs round forward under the characteristic “buffalo hump” of fat.  The adrenal cortex hormones also have weak male hormone effects causing male pattern baldness and excess facial hair in women.  The immune system is weakened and health is further damaged by diabetes, high blood pressure and heart disease.

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